ZNF281 Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 1q32.1
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding
Biological Process:  embryonic body morphogenesis; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; regulation of DNA-templated transcription; stem cell differentiation
Reference #:  Q9Y2X9 (UniProtKB)
Alt. Names/Synonyms: FLJ12859; FLJ14378; GC-box-binding zinc finger protein 1; GZP1; Transcription factor ZBP-99; ZBP-99; ZBP99; Zinc finger DNA-binding protein 99; Zinc finger protein 281; ZN281; ZNF281; ZNP-99; ZNP-99 transcription factor
Gene Symbols: ZNF281
Molecular weight: 96,915 Da
Basal Isoelectric point: 8.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein