NOT2 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. Belongs to the CNOT2/3/5 family. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 12q15
Cellular Component:  CCR4-NOT complex; cytoplasm; cytosol; nucleus; plasma membrane
Molecular Function:  protein binding; RNA polymerase II transcription corepressor binding; transcription coregulator activity
Biological Process:  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; gene silencing by RNA; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription by RNA polymerase II; nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of cytoplasmic mRNA processing body assembly; regulation of stem cell population maintenance; regulation of transcription by RNA polymerase II; RNA phosphodiester bond hydrolysis, exonucleolytic; trophectodermal cell differentiation
Disease: Intellectual Developmental Disorder With Nasal Speech, Dysmorphic Facies, And Variable Skeletal Anomalies
Reference #:  Q9NZN8 (UniProtKB)
Alt. Names/Synonyms: CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; CDC36; CNOT2; FLJ26456; HSPC131; IDNADFS; negative regulator of transcription 2; NOT2; NOT2 (negative regulator of transcription 2, yeast) homolog; NOT2H
Gene Symbols: CNOT2
Molecular weight: 59,738 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein