PKCD an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Note: This description may include information from UniProtKB.
Protein type: AGC group; Delta subfamily; EC; Kinase, protein; Nuclear receptor co-regulator; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; extracellular region; intercellular junction; nuclear matrix; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  ATP binding; calcium-independent protein kinase C activity; enzyme activator activity; enzyme binding; insulin receptor substrate binding; kinase binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein kinase C activity; protein serine/threonine kinase activity
Biological Process:  activation of protein kinase activity; apoptosis; B cell proliferation; cell cycle; cellular response to angiotensin; cellular response to hydrogen peroxide; cellular response to hydroperoxide; cellular senescence; defense response to bacterium; Fc-gamma receptor signaling pathway involved in phagocytosis; histone phosphorylation; immunoglobulin mediated immune response; induction of apoptosis by oxidative stress; interleukin-10 production; interleukin-12 production; negative regulation of actin filament polymerization; negative regulation of filopodium formation; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of platelet aggregation; negative regulation of protein binding; neutrophil activation; neutrophil degranulation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; platelet activation; positive regulation of apoptotic signaling pathway; positive regulation of ceramide biosynthetic process; positive regulation of endodeoxyribonuclease activity; positive regulation of glucosylceramide catabolic process; positive regulation of phospholipid scramblase activity; positive regulation of protein dephosphorylation; positive regulation of protein import into nucleus; positive regulation of response to DNA damage stimulus; positive regulation of sphingomyelin catabolic process; positive regulation of superoxide anion generation; protein amino acid phosphorylation; protein stabilization; regulation of actin cytoskeleton organization; regulation of mRNA stability; regulation of receptor activity; signal transduction; stimulatory C-type lectin receptor signaling pathway
Disease: Autoimmune Lymphoproliferative Syndrome, Type Iii
Reference #:  Q05655 (UniProtKB)
Alt. Names/Synonyms: KPCD; MAY1; MGC49908; nPKC-delta; PKCD; PRKCD; Protein kinase C delta type; protein kinase C delta VIII; protein kinase C, delta
Gene Symbols: PRKCD
Molecular weight: 77,505 Da
Basal Isoelectric point: 7.93  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein