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NOLA1
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Belongs to the GAR1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus; RNA processing; RNA-binding |
| Chromosomal Location of human Ortholog: 4q25 |
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Cellular Component:
box H/ACA scaRNP complex; box H/ACA snoRNP complex; box H/ACA telomerase RNP complex; chromosome, telomeric region; fibrillar center; nucleoplasm; telomerase holoenzyme complex
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Molecular Function:
box H/ACA snoRNA binding; protein binding; RNA binding; telomerase RNA binding
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Biological Process:
snoRNA guided rRNA pseudouridine synthesis; telomere maintenance via telomerase
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Reference #:
Q9NY12
(UniProtKB)
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Alt. Names/Synonyms: GAR1; GAR1 homolog, ribonucleoprotein; GAR1 ribonucleoprotein; GAR1 ribonucleoprotein homolog; GAR1 ribonucleoprotein homolog (yeast); H/ACA ribonucleoprotein complex subunit 1; NOLA1; Nucleolar protein family A member 1; nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs); snoRNP protein GAR1
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Gene Symbols: GAR1
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Molecular weight:
22,348 Da
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Basal Isoelectric point:
10.91
Predict pI for various phosphorylation states
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