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RBM22
Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. Belongs to the SLT11 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: RNA processing; RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of Human Ortholog: 18|18 D3 |
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Cellular Component:
catalytic step 2 spliceosome; cytoplasm; nucleus; spliceosomal complex; U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome
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Molecular Function:
calcium-dependent protein binding; metal ion binding; nucleic acid binding; RNA binding; U6 snRNA binding
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Biological Process:
mRNA cis splicing, via spliceosome; mRNA processing; positive regulation of protein export from nucleus; positive regulation of protein import into nucleus; positive regulation of RNA splicing; protein import into nucleus, translocation; RNA splicing; spliceosomal snRNP biogenesis
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Reference #:
Q8BHS3
(UniProtKB)
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Alt. Names/Synonyms: 8430430L24Rik; MGC91134; Pre-mRNA-splicing factor RBM22; Rbm22; RNA binding motif protein 22; RNA-binding motif protein 22
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Gene Symbols: Rbm22
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Molecular weight:
46,896 Da
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Basal Isoelectric point:
8.83
Predict pI for various phosphorylation states
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