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AMBRA1
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Autophagy; Ubiquitin ligase; Vesicle |
| Chromosomal Location of mouse Ortholog: 2|2 E1 |
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Cellular Component:
anchoring junction; axoneme; Cul4-RING E3 ubiquitin ligase complex; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endoplasmic reticulum; intracellular membrane-bounded organelle; mitochondrion; nucleus; phagocytic vesicle
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Molecular Function:
GTPase binding; protein binding; protein phosphatase binding; ubiquitin ligase-substrate adaptor activity; ubiquitin protein ligase binding
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Biological Process:
autophagosome assembly; autophagy; autophagy of mitochondrion; cell cycle; cell differentiation; embryo development; mitophagy; multicellular organism development; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell population proliferation; negative regulation of neuron apoptotic process; nervous system development; neural tube development; positive regulation of autophagy; positive regulation of free ubiquitin chain polymerization; positive regulation of mitophagy; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein dephosphorylation; positive regulation of regulatory T cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; response to mitochondrial depolarisation
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Reference #:
A2AH22
(UniProtKB)
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Alt. Names/Synonyms: 2310079H06Rik; A130023A14; AA474864; activating molecule in Beclin1-regulated autophagy; Activating molecule in BECN1-regulated autophagy protein 1; Ambra1; AMRA1; autophagy/beclin 1 regulator 1; AV021921; D030051N19Rik; Kiaa1736; mKIAA1736; OTTMUSP00000015140; OTTMUSP00000015141
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Gene Symbols: Ambra1
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Molecular weight:
142,879 Da
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Basal Isoelectric point:
6.54
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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