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AMBRA1
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Autophagy; Ubiquitin ligase; Vesicle |
| Chromosomal Location of human Ortholog: 11p11.2 |
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Cellular Component:
autophagosome; axoneme; Cul4-RING E3 ubiquitin ligase complex; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; focal adhesion; intracellular membrane-bounded organelle; mitochondrial outer membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; phagocytic vesicle
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Molecular Function:
GTPase binding; protein binding; protein phosphatase binding; ubiquitin ligase-substrate adaptor activity; ubiquitin protein ligase binding
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Biological Process:
autophagosome assembly; autophagy; autophagy of mitochondrion; cell cycle; cell differentiation; cellular response to starvation; mitophagy; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell population proliferation; negative regulation of neuron apoptotic process; neural tube development; positive regulation of autophagy; positive regulation of free ubiquitin chain polymerization; positive regulation of mitophagy; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein dephosphorylation; positive regulation of regulatory T cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; response to mitochondrial depolarisation
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Reference #:
Q9C0C7
(UniProtKB)
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Alt. Names/Synonyms: activating molecule in beclin-1-regulated autophagy; Activating molecule in BECN1-regulated autophagy protein 1; AMBRA1; AMRA1; autophagy and beclin 1 regulator 1; autophagy/beclin-1 regulator 1; DCAF3; DDB1 and CUL4 associated factor 3; FLJ20294; KIAA1736; MGC33725; WD repeat domain 94; WDR94
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Gene Symbols: AMBRA1
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Molecular weight:
142,507 Da
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Basal Isoelectric point:
6.73
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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