AMBRA1 Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Ubiquitin ligase; Vesicle
Chromosomal Location of human Ortholog: 11p11.2
Cellular Component:  autophagosome; axoneme; Cul4-RING E3 ubiquitin ligase complex; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; focal adhesion; intracellular membrane-bounded organelle; mitochondrial outer membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; phagocytic vesicle
Molecular Function:  GTPase binding; protein binding; protein phosphatase binding; ubiquitin ligase-substrate adaptor activity; ubiquitin protein ligase binding
Biological Process:  autophagosome assembly; autophagy; autophagy of mitochondrion; cell cycle; cell differentiation; cellular response to starvation; mitophagy; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell population proliferation; negative regulation of neuron apoptotic process; neural tube development; positive regulation of autophagy; positive regulation of free ubiquitin chain polymerization; positive regulation of mitophagy; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein dephosphorylation; positive regulation of regulatory T cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; response to mitochondrial depolarisation
Reference #:  Q9C0C7 (UniProtKB)
Alt. Names/Synonyms: activating molecule in beclin-1-regulated autophagy; Activating molecule in BECN1-regulated autophagy protein 1; AMBRA1; AMRA1; autophagy and beclin 1 regulator 1; autophagy/beclin-1 regulator 1; DCAF3; DDB1 and CUL4 associated factor 3; FLJ20294; KIAA1736; MGC33725; WD repeat domain 94; WDR94
Gene Symbols: AMBRA1
Molecular weight: 142,507 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein