WAC Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 18|18 A1
Cellular Component:  nucleoplasm; nucleus; spliceosomal complex
Molecular Function:  chromatin binding; RNA polymerase II complex binding
Biological Process:  cellular response to DNA damage stimulus; chromatin organization; histone H2B conserved C-terminal lysine ubiquitination; histone monoubiquitination; mitotic G1 DNA damage checkpoint signaling; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of DNA-templated transcription; positive regulation of macroautophagy; positive regulation of TORC1 signaling; regulation of autophagy
Reference #:  Q924H7 (UniProtKB)
Alt. Names/Synonyms: 1110067P07Rik; A230035H12Rik; AI256735; AI256776; Kiaa1844; Wac; WW domain containing adaptor with coiled-coil; WW domain-containing adapter protein with coiled-coil; WW domain-containing protein 4; Wwp; Wwp4
Gene Symbols: Wac
Molecular weight: 70,680 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene