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WAC
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 10p12.1|10p12.1-p11.2 |
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Cellular Component:
nuclear speck; nucleoplasm; nucleus; spliceosomal complex
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Molecular Function:
chromatin binding; protein binding; RNA polymerase II complex binding
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Biological Process:
chromatin remodeling; DNA damage response; mitotic G1 DNA damage checkpoint signaling; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of DNA-templated transcription; positive regulation of macroautophagy; positive regulation of TORC1 signaling; regulation of autophagy
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Disease: Desanto-shinawi Syndrome
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Reference #:
Q9BTA9
(UniProtKB)
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Alt. Names/Synonyms: 1110067P07Rik; bA48B24; bA48B24.1; BM-016; DESSH; KIAA1844; MGC10753; PRO1741; WAC; WW domain containing adaptor with coiled-coil; WW domain-containing adapter protein with coiled-coil; WW domain-containing adaptor with coiled coil; Wwp4
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Gene Symbols: WAC
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Molecular weight:
70,724 Da
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Basal Isoelectric point:
9.49
Predict pI for various phosphorylation states
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