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TCF12
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of Human Ortholog: 9 D|9 39.85 cM |
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Cellular Component:
cytoplasm; intracellular membrane-bounded organelle; nuclear chromatin; nuclear speck; nucleoplasm; nucleus; RNA polymerase II transcription factor complex; transcription factor complex
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Molecular Function:
bHLH transcription factor binding; cAMP response element binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; E-box binding; HMG box domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; SMAD binding; transcription factor binding
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Biological Process:
cell differentiation; multicellular organism development; nervous system development; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated
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Reference #:
Q61286
(UniProtKB)
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Alt. Names/Synonyms: A130037E08Rik; Alf1; bHLHb20; Class A helix-loop-helix transcription factor ME1; DNA-binding protein HTF4; E-box-binding protein; HEB; HTF-4; HTF4; ME1; Meb; REB; TCF-12; Tcf12; Transcription factor 12; Transcription factor HTF-4
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Gene Symbols: Tcf12
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Molecular weight:
75,811 Da
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Basal Isoelectric point:
6.4
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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