TCF12 Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 9 D|9 39.85 cM
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; nuclear chromatin; nuclear speck; nucleoplasm; nucleus; RNA polymerase II transcription factor complex; transcription factor complex
Molecular Function:  bHLH transcription factor binding; cAMP response element binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; E-box binding; HMG box domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; SMAD binding; transcription factor binding
Biological Process:  cell differentiation; multicellular organism development; nervous system development; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated
Reference #:  Q61286 (UniProtKB)
Alt. Names/Synonyms: A130037E08Rik; Alf1; bHLHb2; bHLHb20; Class A helix-loop-helix transcription factor ME1; DNA-binding protein HTF4; E-box-binding protein; HEB; HEBA; HEBAlt; HTF-4; HTF4; ME1; Meb; REB; TCF-12; Tcf12; Transcription factor 12; Transcription factor HTF-4
Gene Symbols: Tcf12
Molecular weight: 75,811 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene