TCF12 Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 15q21.3
Cellular Component:  chromatin; cytoplasm; intracellular membrane-bounded organelle; nuclear speck; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex
Molecular Function:  bHLH transcription factor binding; cAMP response element binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; E-box binding; HMG box domain binding; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; SMAD binding; transcription cis-regulatory region binding
Biological Process:  cell differentiation; gene expression; immune response; muscle organ development; nervous system development; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; response to gonadotropin-releasing hormone
Disease: Craniosynostosis 3; Hypogonadotropic Hypogonadism 26 With Or Without Anosmia
Reference #:  Q99081 (UniProtKB)
Alt. Names/Synonyms: bHLHb20; class B basic helix-loop-helix protein 20; CRS3; DNA-binding protein HTF4; E-box-binding protein; HEB; helix-loop-helix transcription factor 4; Helix-loop-helix transcription factor 4 isoform c; HsT17266; HTF4; p64; TCF-12; TCF12; Transcription factor 12; Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4), isoform CRA_b; transcription factor HTF-4
Gene Symbols: TCF12
Molecular weight: 72,965 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB