nectin 4 Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus. Belongs to the nectin family. Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1|1 H3
Cellular Component:  adherens junction; apical junction complex; cell junction; cell-cell adherens junction; integral component of membrane; membrane; plasma membrane
Molecular Function:  cell adhesion molecule binding; identical protein binding; protein homodimerization activity; signaling receptor activity
Biological Process:  cell adhesion; cell-cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; viral entry into host cell
Reference #:  Q8R007 (UniProtKB)
Alt. Names/Synonyms: 1200017F15Rik; Ig superfamily receptor LNIR; Lnir; NECT4; nectin 4; Nectin cell adhesion molecule 4; Nectin-4; Nectin4; OTTMUSP00000024108; poliovirus receptor-related 4; Poliovirus receptor-related protein 4; Prr4; Pvrl4
Gene Symbols: Pvrl4
Molecular weight: 55,657 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Select Structure to View Below

nectin 4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene