EDC3 Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. Belongs to the EDC3 family. Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland. Note: This description may include information from UniProtKB.
Protein type: RNA processing
Chromosomal Location of human Ortholog: 15q24.1
Cellular Component:  cytoplasmic ribonucleoprotein granule; cytosol
Molecular Function:  identical protein binding; phosphodiesterase decapping endonuclease activity; protein binding
Biological Process:  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; RNA phosphodiester bond hydrolysis, endonucleolytic
Disease: Mental Retardation, Autosomal Recessive 50
Reference #:  Q96F86 (UniProtKB)
Alt. Names/Synonyms: EDC3; enhancer of mRNA decapping 3; enhancer of mRNA decapping 3 homolog; enhancer of mRNA decapping 3 homolog (S. cerevisiae); Enhancer of mRNA-decapping protein 3; FLJ21128; FLJ31777; hYjeF_N2; hYjeF_N2-15q23; LSM16; LSM16 homolog; LSM16 homolog (EDC3, S. cerevisiae); MRT50; YJDC; yjeF domain containing; YjeF domain-containing protein 1; YjeF N-terminal domain-containing protein 2; YjeF_N2; YJEFN2
Gene Symbols: EDC3
Molecular weight: 56,078 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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EDC3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein