MMRP19 Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; Apoptosis; EC 4.2.1.109
Chromosomal Location of Human Ortholog: 2|2 E2
Cellular Component:  cytoplasm
Molecular Function:  identical protein binding; lyase activity; metal ion binding; methylthioribulose 1-phosphate dehydratase activity; zinc ion binding
Biological Process:  apoptotic process; cellular amino acid biosynthetic process; L-methionine salvage from methylthioadenosine; methionine biosynthetic process; negative regulation of apoptotic process; protein homotetramerization; pyroptosis; regulation of ERK1 and ERK2 cascade
Reference #:  Q9WVQ5 (UniProtKB)
Alt. Names/Synonyms: APAF1 interacting protein; APAF1-interacting protein; Apip; APIP2; CGI-2; CGI-29; Methylthioribulose-1-phosphate dehydratase; Mmrp; Mmrp19; monocyte macrophage 19; Monocyte/macrophage protein 19; MTNB; MTRu-1-P dehydratase; OTTMUSP00000015746; Probable methylthioribulose-1-phosphate dehydratase
Gene Symbols: Apip
Molecular weight: 26,949 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
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MMRP19

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene