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MMRP19
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - cysteine and methionine; Apoptosis; EC 4.2.1.109 |
| Chromosomal Location of human Ortholog: 11p13 |
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Cellular Component:
cytoplasm; cytosol
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Molecular Function:
identical protein binding; methylthioribulose 1-phosphate dehydratase activity; protein binding; zinc ion binding
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Biological Process:
apoptotic process; L-methionine salvage from methylthioadenosine; L-methionine salvage from S-adenosylmethionine; negative regulation of apoptotic process; protein homotetramerization; pyroptosis; regulation of ERK1 and ERK2 cascade
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Reference #:
Q96GX9
(UniProtKB)
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Alt. Names/Synonyms: APAF1 interacting protein; APAF1-interacting protein; APIP; APIP2; CGI-29; CGI29; dJ179L10.2; hAPIP; Methylthioribulose-1-phosphate dehydratase; MMRP19; MTNB; MTRu-1-P dehydratase; Probable methylthioribulose-1-phosphate dehydratase
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Gene Symbols: APIP
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Molecular weight:
27,125 Da
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Basal Isoelectric point:
6.7
Predict pI for various phosphorylation states
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