MMRP19 Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; Apoptosis; EC 4.2.1.109
Chromosomal Location of human Ortholog: 11p13
Cellular Component:  cytoplasm; cytosol
Molecular Function:  identical protein binding; methylthioribulose 1-phosphate dehydratase activity; protein binding; zinc ion binding
Biological Process:  apoptotic process; L-methionine salvage from methylthioadenosine; L-methionine salvage from S-adenosylmethionine; negative regulation of apoptotic process; protein homotetramerization; pyroptosis; regulation of ERK1 and ERK2 cascade
Reference #:  Q96GX9 (UniProtKB)
Alt. Names/Synonyms: APAF1 interacting protein; APAF1-interacting protein; APIP; APIP2; CGI-29; CGI29; dJ179L10.2; hAPIP; Methylthioribulose-1-phosphate dehydratase; MMRP19; MTNB; MTRu-1-P dehydratase; Probable methylthioribulose-1-phosphate dehydratase
Gene Symbols: APIP
Molecular weight: 27,125 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
Select Structure to View Below

MMRP19

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene