INTS7 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Belongs to the Integrator subunit 7 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of mouse Ortholog: 1|1 H6
Cellular Component:  chromosome; cytoplasm; integrator complex; nuclear body; nucleus
Biological Process:  cellular response to DNA damage stimulus; cellular response to ionizing radiation; DNA damage checkpoint signaling; snRNA 3'-end processing; snRNA processing
Reference #:  Q7TQK1 (UniProtKB)
Alt. Names/Synonyms: 5930412E23Rik; Int7; Integrator complex subunit 7; Ints7
Gene Symbols: Ints7
Molecular weight: 106,861 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene