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INTS7
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Belongs to the Integrator subunit 7 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 1|1 H6 |
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Cellular Component:
chromosome; cytoplasm; integrator complex; nuclear body; nucleus
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Biological Process:
cellular response to DNA damage stimulus; cellular response to ionizing radiation; DNA damage checkpoint signaling; snRNA 3'-end processing; snRNA processing
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Reference #:
Q7TQK1
(UniProtKB)
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Alt. Names/Synonyms: 5930412E23Rik; Int7; Integrator complex subunit 7; Ints7
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Gene Symbols: Ints7
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Molecular weight:
106,861 Da
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Basal Isoelectric point:
8.54
Predict pI for various phosphorylation states
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