INTS7 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Belongs to the Integrator subunit 7 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 1q32.3
Cellular Component:  chromosome; cytoplasm; integrator complex; nuclear body; nucleoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  cellular response to ionizing radiation; DNA damage checkpoint; snRNA processing; snRNA transcription by RNA polymerase II
Reference #:  Q9NVH2 (UniProtKB)
Alt. Names/Synonyms: C1orf73; DKFZp434B168; Int7; Integrator complex subunit 7; INTS7
Gene Symbols: INTS7
Molecular weight: 106,834 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein