PIAS4 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Belongs to the PIAS family. Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; SUMO conjugating system; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10|10 C1
Cellular Component:  cytoplasm; nuclear matrix; nucleoplasm; nucleus; transferase complex
Molecular Function:  DNA binding; metal ion binding; protein binding; protein C-terminus binding; SUMO ligase activity; SUMO transferase activity; transcription corepressor activity; transferase activity; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  JAK-STAT cascade; multicellular organism development; negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of keratinocyte apoptotic process; positive regulation of protein sumoylation; protein sumoylation; viral process; Wnt signaling pathway
Reference #:  Q9JM05 (UniProtKB)
Alt. Names/Synonyms: E3 SUMO-protein ligase PIAS4; PIAS-gamma; Pias4; Piasg; PIASy; protein inhibitor of activated STAT 4; protein inhibitor of activated STAT PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; RING-type E3 ubiquitin transferase PIAS4
Gene Symbols: Pias4
Molecular weight: 55,570 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling  |  NF-kB Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA