DDX17
an RNA helicase that unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in pre-mRNA splicing, alternative splicing, ribosomal RNA processing, miRNA processing, and transcription regulation. Regulates the alternative splicing of exons exhibiting specific features. For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts. Affects NFAT5 and H2AFY alternative splicing in a CDK9-dependent manner. Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663, MIR99B, and MIR6087. Required for the production of subsets of microRNAs, including MIR21 and MIR125B1. Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA. Enhances NFAT5 transcriptional activity, and synergizes with TP53 in the activation of the MDM2 promoter. Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin CCND1 transcription. Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes. During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression. Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes. Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent. Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. Widely expressed. Low expression, if any, in normal colonic epithelial cells (at protein level). Levels tend to increase during colon cancer progression, from very low in benign hyperplastic polyps to very high in tubular and villous adenomas . 4 isoforms generated by alternative splicing or alternative initiation have been reported. Note: This description may include information from UniProtKB.
