IRF2BP1 Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. Belongs to the IRF2BP family. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 7|7 A3
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription corepressor activity; transcription factor binding; transferase activity; ubiquitin protein ligase activity
Biological Process:  negative regulation of transcription by RNA polymerase II; protein polyubiquitination
Reference #:  Q8R3Y8 (UniProtKB)
Alt. Names/Synonyms: 6330414O09Rik; C530033F24; I2BP1; interferon regulatory factor 2 binding protein 1; Interferon regulatory factor 2-binding protein 1; IRF-2-binding protein 1; IRF-2BP1; Irf2bp1; Probable E3 ubiquitin-protein ligase IRF2BP1; Probable RING-type E3 ubiquitin transferase IRF2BP1
Gene Symbols: Irf2bp1
Molecular weight: 61,751 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene