HuR RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR. Belongs to the RRM elav family. Ubiquitous. Detected in brain, liver, thymus and muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of human Ortholog: 19p13.2
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytoplasmic vesicle; cytosol; endoplasmic reticulum; glutamatergic synapse; nucleoplasm; nucleus; P-body; postsynapse; ribonucleoprotein complex; sarcoplasm
Molecular Function:  double-stranded RNA binding; lncRNA binding; miRNA binding; mRNA 3'-UTR AU-rich region binding; mRNA 3'-UTR binding; mRNA binding; protein binding; protein homodimerization activity; protein kinase binding; RNA binding
Biological Process:  3'-UTR-mediated mRNA stabilization; mRNA stabilization; negative regulation of miRNA-mediated gene silencing; positive regulation of translation; post-transcriptional gene silencing; protein homooligomerization; protein import into nucleus; regulation of stem cell population maintenance
Reference #:  Q15717 (UniProtKB)
Alt. Names/Synonyms: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV like RNA binding protein 1; ELAV-like protein 1; ELAV1; ELAVL1; embryonic lethal, abnormal vision, drosophila, homolog-like 1; Hu antigen R; Hu-antigen R; Hua; HUR; MelG
Gene Symbols: ELAVL1
Molecular weight: 36,092 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HuR

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein