NFI-X Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 8 C2|8 41.02 cM
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
Biological Process:  astrocyte differentiation; cerebellar granule cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; DNA replication; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
Reference #:  P70257 (UniProtKB)
Alt. Names/Synonyms: CCAAT-box-binding transcription factor; CTF; NF-I/X; NF1-X; NFI-X; Nfix; Nuclear factor 1 X-type; Nuclear factor 1/X; Nuclear factor I/X; OTTMUSP00000025025; OTTMUSP00000025026; OTTMUSP00000025027; TGGCA-binding protein
Gene Symbols: Nfix
Molecular weight: 53,394 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene