NFI-X Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 8 C2|8 41.02 cM
Cellular Component:  nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
Biological Process:  astrocyte differentiation; atrioventricular canal morphogenesis; bone mineralization; brain development; brain morphogenesis; camera-type eye development; cell maturation; cell morphogenesis; cell proliferation in forebrain; cell quiescence; cellular response to BMP stimulus; cerebellar cortex morphogenesis; cerebellar granule cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; cerebral cortex development; collateral sprouting; DNA replication; ear development; endochondral ossification; epithelium development; exit from mitosis; forebrain development; forebrain radial glial cell differentiation; gene expression; generation of neurons; glial cell development; glial cell fate specification; glial cell proliferation; gliogenesis; hippocampus development; homeostasis of number of cells within a tissue; inflammatory response; lateral ventricle development; learning; macrophage differentiation; memory; multicellular organism growth; negative regulation of neuron apoptotic process; negative regulation of transcription by RNA polymerase II; neural precursor cell proliferation; neuroblast differentiation; neuroblast migration; neuroblast proliferation; neurogenesis; neuron differentiation; neuron fate specification; olfactory bulb development; oligodendrocyte differentiation; osteoclast differentiation; osteoclast proliferation; phagocytosis; positive regulation of transcription by RNA polymerase II; regeneration; regulation of DNA-binding transcription factor activity; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to wounding; retina development in camera-type eye; Rho protein signal transduction; skeletal muscle satellite cell differentiation; skeletal muscle tissue development; skeletal muscle tissue regeneration; skeletal system development; social behavior; spinal cord development; stem cell population maintenance; tissue homeostasis; transcription by RNA polymerase II
Reference #:  P70257 (UniProtKB)
Alt. Names/Synonyms: CCAAT-box-binding transcription factor; CTF; NF-I/X; NF1-X; NFI-X; Nfix; Nuclear factor 1 X-type; Nuclear factor 1/X; Nuclear factor I/X; OTTMUSP00000025025; OTTMUSP00000025026; OTTMUSP00000025027; TGGCA-binding protein
Gene Symbols: Nfix
Molecular weight: 53,394 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene