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NFI-X
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 8 C2|8 41.02 cM |
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Cellular Component:
nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
astrocyte differentiation; cerebellar granule cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; DNA replication; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
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Reference #:
P70257
(UniProtKB)
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Alt. Names/Synonyms: CCAAT-box-binding transcription factor; CTF; NF-I/X; NF1-X; NFI-X; Nfix; Nuclear factor 1 X-type; Nuclear factor 1/X; Nuclear factor I/X; OTTMUSP00000025025; OTTMUSP00000025026; OTTMUSP00000025027; TGGCA-binding protein
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Gene Symbols: Nfix
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Molecular weight:
53,394 Da
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Basal Isoelectric point:
8.9
Predict pI for various phosphorylation states
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