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NFI-X
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 19p13.13 |
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Cellular Component:
chromatin; nucleus
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Molecular Function:
DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
DNA replication; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II
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Disease: Marshall-smith Syndrome; Sotos Syndrome 2
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Reference #:
Q14938
(UniProtKB)
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Alt. Names/Synonyms: CCAAT-box-binding transcription factor; CTF; MRSHSS; NF-I/X; NF1-X; NF1A; NFI-X; NFIX; Nuclear factor 1 X-type; Nuclear factor 1/X; nuclear factor I X; Nuclear factor I/X; nuclear factor I/X (CCAAT-binding transcription factor); SOTOS2; TGGCA-binding protein
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Gene Symbols: NFIX
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Molecular weight:
55,098 Da
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Basal Isoelectric point:
8.9
Predict pI for various phosphorylation states
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