MCM6 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Belongs to the MCM family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC
Chromosomal Location of mouse Ortholog: 1 E3|1 55.8 cM
Cellular Component:  MCM complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA binding; DNA replication origin binding; helicase activity; hydrolase activity; identical protein binding; nucleotide binding; protein binding; single-stranded DNA binding
Biological Process:  cell cycle; DNA replication; DNA replication initiation; DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; mitotic DNA replication; pre-replicative complex assembly involved in nuclear cell cycle DNA replication
Reference #:  P97311 (UniProtKB)
Alt. Names/Synonyms: ASP-l1; D1Wsu22; D1Wsu22e; DNA replication licensing factor MCM6; Mcm6; Mcmd6; mini chromosome maintenance deficient 6; minichromosome maintenance complex component 6; minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe); minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae); Mis5; Mis5 homolog
Gene Symbols: Mcm6
Molecular weight: 92,867 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene