MCM6 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Belongs to the MCM family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC
Chromosomal Location of Human Ortholog: 2q21.3
Cellular Component:  MCM complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; identical protein binding; protein binding; single-stranded DNA binding
Biological Process:  DNA replication; DNA replication initiation; DNA unwinding involved in DNA replication; G1/S transition of mitotic cell cycle
Disease: Lactose Intolerance, Adult Type
Reference #:  Q14566 (UniProtKB)
Alt. Names/Synonyms: DNA replication licensing factor MCM6; MCG40308; MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe); minichromosome maintenance complex component 6; minichromosome maintenance deficient (mis5, S. pombe) 6; minichromosome maintenance deficient 6 homolog; Mis5; MIS5 homolog; p105MCM
Gene Symbols: MCM6
Molecular weight: 92,889 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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