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MORC3
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity. Binds RNA in vitro. May be required for influenza A transcription during viral infection. Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; RNA-binding |
| Chromosomal Location of mouse Ortholog: 16|16 C4 |
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Cellular Component:
chromatin; chromosome; nucleoplasm; nucleus; PML body
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Molecular Function:
ATP hydrolysis activity; DNA binding; metal ion binding; methylated histone binding; protein-macromolecule adaptor activity; RNA binding; zinc ion binding
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Biological Process:
antiviral innate immune response; immune system process; innate immune response; maintenance of protein location in nucleus; negative regulation of fibroblast proliferation; negative regulation of interferon-beta production; negative regulation of transcription by RNA polymerase II; peptidyl-serine phosphorylation; positive regulation of cellular senescence; post-embryonic development; protein phosphorylation; protein stabilization
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Reference #:
F7BJB9
(UniProtKB)
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Alt. Names/Synonyms: 1110051N18Rik; AI452146; BF318192; D16Jhu32e; microrchidia 3; mKIAA0136; MKIAA0136 protein; MORC family CW-type zinc finger protein 3; Morc3; Nuclear matrix protein 2; NXP2; Zcwcc3; Zinc finger CW-type coiled-coil domain protein 3; zinc finger, CW-type with coiled-coil domain 3
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Gene Symbols: Morc3
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Molecular weight:
106,522 Da
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Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
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