MORC3 Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26202233}. Homodimer (PubMed:17332504). The sumoylated form interacts with PML (via SUMO-interacting motif) (PubMed:20501696, PubMed:17332504). Interacts with PT53 (PubMed:17332504). Interacts with influenza A virus PA and PB1 polymerase subunits during infection (PubMed:26202233). {ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26202233}.
Protein type: Cell cycle regulation; RNA-binding
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component:  nuclear matrix; nucleoplasm; PML body
Molecular Function:  RNA binding; zinc ion binding
Biological Process:  cell aging; maintenance of protein location in nucleus; negative regulation of fibroblast proliferation; peptidyl-serine phosphorylation; post-embryonic development; protein phosphorylation; protein stabilization; viral process
Reference #:  Q14149 (UniProtKB)
Alt. Names/Synonyms: KIAA0136; MORC family CW-type zinc finger 3; MORC family CW-type zinc finger protein 3; MORC3; nuclear matrix protein NXP2; NXP2; ZCW5; ZCWCC3; Zinc finger CW-type coiled-coil domain protein 3; zinc finger, CW type with coiled-coil domain 3; zinc finger, CW-type with coiled-coil domain 3
Gene Symbols: MORC3
Molecular weight: 107,113 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB