FLI1 Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. Belongs to the ETS family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of mouse Ortholog: 9 A4|9 17.74 cM
Cellular Component:  cytosol; nuclear body; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  animal organ morphogenesis; blood circulation; cell differentiation; cellular process; megakaryocyte development; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  P26323 (UniProtKB)
Alt. Names/Synonyms: EWS; EWSR2; Fli; Fli-1; Fli1; Friend leukemia integration 1; Friend leukemia integration 1 transcription factor; Retroviral integration site protein Fli-1; SIC; SIC-1; Sic1
Gene Symbols: Fli1
Molecular weight: 51,002 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FLI1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene