FLI1 Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. Belongs to the ETS family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of human Ortholog: 11q24.3
Cellular Component:  chromatin; cytosol; nuclear body; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding
Biological Process:  animal organ morphogenesis; blood circulation; cell differentiation; hemostasis; megakaryocyte development; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
Disease: Bleeding Disorder, Platelet-type, 21
Reference #:  Q01543 (UniProtKB)
Alt. Names/Synonyms: BDPLT21; Ewing sarcoma breakpoint region 2; EWSR2; Fli-1 proto-oncogene, ETS transcription factor; FLI1; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; Proto-oncogene Fli-1; SIC-1; Transcription factor ERGB
Gene Symbols: FLI1
Molecular weight: 50,982 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FLI1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein