RIL Isoform 1: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons. Isoform 2: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. Isoform 2 is found in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component:  cell junction; cytoplasm; cytoskeleton; dendritic spine; early endosome lumen; early endosome membrane; filamentous actin; lamellipodium; nucleus; perinuclear region of cytoplasm; postsynaptic membrane; recycling endosome lumen; recycling endosome membrane; stress fiber
Molecular Function:  alpha-actinin binding; metal ion binding; protein binding; protein homodimerization activity; protein phosphatase binding
Biological Process:  actin cytoskeleton reorganization; excitatory chemical synaptic transmission
Disease: Osteoporosis
Reference #:  P50479 (UniProtKB)
Alt. Names/Synonyms: enigma homolog; LIM domain protein; LIM protein RIL; PDLI4; PDLIM4; PDZ and LIM domain 4; PDZ and LIM domain protein 4; Reversion-induced LIM protein; RIL
Gene Symbols: PDLIM4
Molecular weight: 35,398 Da
Basal Isoelectric point: 8.07  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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