LIG3 Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair. Belongs to the ATP-dependent DNA ligase family. Testis, thymus, prostate and heart. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.5.1.1; Ligase
Chromosomal Location of Human Ortholog: 11 C|11 50.23 cM
Cellular Component:  condensed nuclear chromosome; cytoplasm; DNA ligase III-XRCC1 complex; mitochondrion; nucleoplasm; nucleus; synaptonemal complex
Molecular Function:  ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; ligase activity; metal ion binding; nucleotide binding; protein binding; zinc ion binding
Biological Process:  base-excision repair, DNA ligation; cell cycle; cell division; cellular response to DNA damage stimulus; DNA biosynthetic process; DNA ligation; DNA ligation involved in DNA repair; DNA recombination; DNA repair; DNA replication; double-strand break repair; double-strand break repair via alternative nonhomologous end joining; double-strand break repair via nonhomologous end joining; lagging strand elongation; mitochondrial DNA repair; mitochondrion organization; negative regulation of DNA recombination; negative regulation of mitochondrial DNA replication
Reference #:  P97386 (UniProtKB)
Alt. Names/Synonyms: D11Wsu78e; DNA ligase (ATP) 3; DNA ligase 3; DNA ligase III; DNLI3; Lig3; ligase III, DNA, ATP-dependent; MGC78176; OTTMUSP00000000875; Polydeoxyribonucleotide synthase [ATP] 3
Gene Symbols: Lig3
Molecular weight: 113,072 Da
Basal Isoelectric point: 9.16  Predict pI for various phosphorylation states
Select Structure to View Below

LIG3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene