MYH10 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 11 B3|11 41.95 cM
Cellular Component:  actomyosin; axon; brush border; cell cortex; cell projection; cleavage furrow; cytoplasm; cytosol; dendritic spine; glutamatergic synapse; growth cone; lamellipodium; midbody; myosin complex; myosin II complex; myosin II filament; neuron projection; neuronal cell body; polysome; postsynaptic actin cytoskeleton; stress fiber
Molecular Function:  actin binding; actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; ATPase activity; calmodulin binding; identical protein binding; microfilament motor activity; motor activity; mRNA 5'-UTR binding; nucleotide binding; protein binding; RNA stem-loop binding
Biological Process:  actin cytoskeleton organization; actin filament bundle assembly; actin filament bundle distribution; actin filament-based movement; actomyosin structure organization; adult heart development; aorta development; axon guidance; axonogenesis; brain development; cardiac myofibril assembly; cardiac septum development; cell adhesion; cell proliferation; cerebellar Purkinje cell layer development; coronary vasculature development; exocytosis; fourth ventricle development; heart development; in utero embryonic development; lateral ventricle development; mitotic cytokinesis; modification of postsynaptic actin cytoskeleton; myofibril assembly; neuromuscular process controlling balance; neuron migration; neuron projection development; nuclear migration; plasma membrane repair; positive regulation of protein secretion; postsynaptic actin cytoskeleton organization; regulation of cell shape; regulation of modification of postsynaptic actin cytoskeleton; retina development in camera-type eye; substrate-dependent cell migration, cell extension; third ventricle development; ventricular cardiac muscle cell development
Reference #:  Q61879 (UniProtKB)
Alt. Names/Synonyms: 5730504C04Rik; 9330167F11Rik; Cellular myosin heavy chain, type B; flectin; Fltn; II-B; MGC115764; mKIAA3005; Myh10; Myhn-2; Myhn2; Myosin heavy chain 10; myosin heavy chain 10, non-muscle; Myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscular, type B; myosin IIB; myosin, heavy polypeptide 10, non-muscle; Myosin-10; NMHC; NMHC-B; NMHCII-B; NMMHC II-b; NMMHC-B; NMMHC-IIB; Non-muscle myosin heavy chain B; Non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain II-B; OTTMUSP00000006152; SMemb
Gene Symbols: Myh10
Molecular weight: 228,996 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MYH10

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein