MYH10 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component:  actomyosin; brush border; cell cortex; cleavage furrow; cytoplasm; cytosol; dendritic spine; glutamatergic synapse; growth cone; lamellipodium; midbody; myosin complex; myosin II complex; myosin II filament; neuromuscular junction; neuronal cell body; polysome; spindle; stress fiber
Molecular Function:  actin binding; actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; ATPase activity; calmodulin binding; microfilament motor activity; mRNA 5'-UTR binding; protein binding; RNA stem-loop binding
Biological Process:  actin filament-based movement; actomyosin structure organization; adult heart development; aorta development; axon guidance; cardiac myofibril assembly; cardiac septum development; cell adhesion; cell proliferation; cerebellar Purkinje cell layer development; coronary vasculature development; exocytosis; fourth ventricle development; in utero embryonic development; lateral ventricle development; mitotic cytokinesis; modification of postsynaptic actin cytoskeleton; neuromuscular process controlling balance; neuron migration; nuclear migration; plasma membrane repair; positive regulation of protein secretion; postsynaptic actin cytoskeleton organization; regulation of cell shape; retina development in camera-type eye; substrate-dependent cell migration, cell extension; third ventricle development; ventricular cardiac muscle cell development
Reference #:  P35580 (UniProtKB)
Alt. Names/Synonyms: Cellular myosin heavy chain, type B; cellular myosin heavy chain, type B type B; MGC134913; MGC134914; MYH10; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscle type B; myosin, heavy chain 10, non-muscle; myosin, heavy polypeptide 10, non-muscle; Myosin-10; near to the ATP binding region; NMMHC II-b; NMMHC-B; NMMHC-IIB; NMMHCB; Non-muscle myosin heavy chain B; Non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain IIB; nonmuscle myosin heavy chain-B; nonmuscle myosin II heavy chain-B
Gene Symbols: MYH10
Molecular weight: 228,999 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MYH10

Protein Structure Not Found.


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