ABCC1 Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Lung, testis and peripheral blood mononuclear cells. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of human Ortholog: 16p13.11
Cellular Component:  apical plasma membrane; basal plasma membrane; basolateral plasma membrane; lateral plasma membrane; plasma membrane
Molecular Function:  ABC-type glutathione S-conjugate transporter activity; ABC-type transporter activity; ABC-type vitamin B12 transporter activity; ABC-type xenobiotic transporter activity; ATP binding; ATP hydrolysis activity; ATPase-coupled inorganic anion transmembrane transporter activity; ATPase-coupled lipid transmembrane transporter activity; ATPase-coupled transmembrane transporter activity; carboxylic acid transmembrane transporter activity; efflux transmembrane transporter activity; glutathione transmembrane transporter activity; xenobiotic transmembrane transporter activity
Biological Process:  carboxylic acid transmembrane transport; cell chemotaxis; cellular response to amyloid-beta; cellular response to oxidative stress; cobalamin transport; cyclic nucleotide transport; export across plasma membrane; glutathione transmembrane transport; heme catabolic process; leukotriene metabolic process; leukotriene transport; monoatomic anion transmembrane transport; phospholipid translocation; positive regulation of inflammatory response; response to xenobiotic stimulus; sphingolipid translocation; transepithelial transport; transmembrane transport; transport across blood-brain barrier; xenobiotic metabolic process; xenobiotic transport; xenobiotic transport across blood-brain barrier
Disease: Deafness, Autosomal Dominant 77
Reference #:  P33527 (UniProtKB)
Alt. Names/Synonyms: ABC29; ABCC; ABCC1; ATP binding cassette subfamily C member 1; ATP-binding cassette sub-family C member 1; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; DFNA77; DKFZp686N04233; DKFZp781G125; Glutathione-S-conjugate-translocating ATPase ABCC1; GS-X; Leukotriene C(4) transporter; LTC4 transporter; MRP; MRP1; multidrug resistance protein; Multidrug resistance-associated protein 1; multiple drug resistance protein 1; multiple drug resistance-associated protein
Gene Symbols: ABCC1
Molecular weight: 171,591 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ABCC1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein