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NFYA
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. Belongs to the NFYA/HAP2 subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 17 C|17 23.99 cM |
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Cellular Component:
CCAAT-binding factor complex; nucleoplasm; nucleus; protein-DNA complex; RNA polymerase II transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coregulator binding
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Biological Process:
histone H3-K4 trimethylation; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of histone acetylation; regulation of transcription by RNA polymerase II; rhythmic process
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Reference #:
P23708
(UniProtKB)
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Alt. Names/Synonyms: AA407810; CAAT box DNA-binding protein subunit A; CAAT-box DNA-binding protein subunit A; Cbf-b; NF-YA; Nfya; Nuclear transcription factor Y subunit A; Nuclear transcription factor Y subunit alpha; nuclear transcription factor-Y alpha; SEZ-10; Sez1; SEZ10
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Gene Symbols: Nfya
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Molecular weight:
36,779 Da
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Basal Isoelectric point:
8.89
Predict pI for various phosphorylation states
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