NFYA Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. Belongs to the NFYA/HAP2 subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 17 C|17 23.99 cM
Cellular Component:  CCAAT-binding factor complex; nucleoplasm; nucleus; protein-DNA complex; RNA polymerase II transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription cofactor binding; transcription factor binding
Biological Process:  positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of stem cell population maintenance; regulation of transcription, DNA-templated; rhythmic process
Reference #:  P23708 (UniProtKB)
Alt. Names/Synonyms: AA407810; CAAT box DNA-binding protein subunit A; CAAT-box DNA-binding protein subunit A; Cbf-b; NF-YA; Nfya; Nuclear transcription factor Y subunit A; Nuclear transcription factor Y subunit alpha; nuclear transcription factor-Y alpha; SEZ-10; Sez1; SEZ10
Gene Symbols: Nfya
Molecular weight: 36,779 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene