NFYA stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. Involved in cisplatin resistance. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component:  CCAAT-binding factor complex; nucleoplasm; nucleus; protein-DNA complex; RNA polymerase II transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  positive regulation of transcription, DNA-templated; regulation of cholesterol biosynthetic process; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; rhythmic process; transcription by RNA polymerase II
Reference #:  P23511 (UniProtKB)
Alt. Names/Synonyms: CAAT box DNA-binding protein subunit A; CAAT-box DNA binding protein subunit A; CBF-A; CBF-B; CCAAT-binding transcription factor subunit B; FLJ11236; HAP2; HAP2 CCAAT-binding protein; NF-YA; NFYA; Nuclear transcription factor Y subunit A; Nuclear transcription factor Y subunit alpha; nuclear transcription factor Y, alpha; Transcription factor NF-Y, A subunit
Gene Symbols: NFYA
Molecular weight: 36,877 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
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NFYA

Protein Structure Not Found.


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