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NFYA
stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. Involved in cisplatin resistance. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of Human Ortholog: 6p21.1 |
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Cellular Component:
CCAAT-binding factor complex; nucleoplasm; nucleus; protein-DNA complex; RNA polymerase II transcription factor complex
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
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Biological Process:
positive regulation of transcription, DNA-templated; regulation of cholesterol biosynthetic process; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; rhythmic process; transcription by RNA polymerase II
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Reference #:
P23511
(UniProtKB)
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Alt. Names/Synonyms: CAAT box DNA-binding protein subunit A; CAAT-box DNA binding protein subunit A; CBF-A; CBF-B; CCAAT-binding transcription factor subunit B; FLJ11236; HAP2; HAP2 CCAAT-binding protein; NF-YA; NFYA; Nuclear transcription factor Y subunit A; Nuclear transcription factor Y subunit alpha; nuclear transcription factor Y, alpha; Transcription factor NF-Y, A subunit
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Gene Symbols: NFYA
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Molecular weight:
36,877 Da
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Basal Isoelectric point:
8.89
Predict pI for various phosphorylation states
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