NFYA Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. Belongs to the NFYA/HAP2 subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 6p21.1
Cellular Component:  CCAAT-binding factor complex; nucleoplasm; nucleus; protein-DNA complex; RNA polymerase II transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  positive regulation of transcription, DNA-templated; regulation of cholesterol biosynthetic process; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; rhythmic process; transcription by RNA polymerase II
Reference #:  P23511 (UniProtKB)
Alt. Names/Synonyms: CAAT box DNA-binding protein subunit A; CAAT-box DNA binding protein subunit A; CBF-A; CBF-B; CCAAT-binding transcription factor subunit B; FLJ11236; HAP2; HAP2 CCAAT-binding protein; NF-YA; NFYA; Nuclear transcription factor Y subunit A; Nuclear transcription factor Y subunit alpha; nuclear transcription factor Y, alpha; Transcription factor NF-Y, A subunit
Gene Symbols: NFYA
Molecular weight: 36,877 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein