SLC34A2 May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. Belongs to the SLC34A transporter family. Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 4p15.2
Cellular Component:  apical plasma membrane; brush border membrane; integral component of membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  phosphate ion binding; sodium ion binding; sodium-dependent phosphate transmembrane transporter activity; sodium:phosphate symporter activity
Biological Process:  cellular phosphate ion homeostasis; cellular protein metabolic process; in utero embryonic development; phosphate ion transport; response to estrogen; sodium ion transmembrane transport
Disease: Pulmonary Alveolar Microlithiasis
Reference #:  O95436 (UniProtKB)
Alt. Names/Synonyms: FLJ90534; Na(+)-dependent phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; NaPi-2b; NAPI-3B; NAPI-IIb; NaPi3b; NPT2B; NPTIIb; PULAM; SLC34A2; Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; sodium-phosphate transporter; Sodium/phosphate cotransporter 2B; solute carrier family 34 (sodium phosphate), member 2; solute carrier family 34 (type II sodium/phosphate cotransporter), member 2; Solute carrier family 34 member 2; type II sodium-dependent phosphate transporter 3b
Gene Symbols: SLC34A2
Molecular weight: 75,759 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein