MICAL2 Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. Belongs to the Mical family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; EC 1.14.13.-
Chromosomal Location of Human Ortholog: 7|7 F1
Cellular Component:  nucleus
Molecular Function:  actin binding; oxidoreductase activity
Biological Process:  actin filament depolymerization; cytoskeleton organization; oxidation-reduction process; positive regulation of transcription via serum response element binding
Reference #:  Q8BML1 (UniProtKB)
Alt. Names/Synonyms: 5330438E18Rik; 9530064J02; [F-actin]-methionine sulfoxide oxidase MICAL2; [F-actin]-monooxygenase MICAL2; F-actin-monooxygenase MICAL2; KIAA0750; MICA2; MICAL-2; Mical2; microtubule associated monooxygenase, calponin and LIM domain containing 2; microtubule associated monoxygenase, calponin and LIM domain containing 2; mKIAA0750; mMical2; Molecule interacting with CasL protein 2; OTTMUSP00000028193; Protein MICAL-2; protein-methionine sulfoxide oxidase MICAL2
Gene Symbols: Mical2
Molecular weight: 110,072 Da
Basal Isoelectric point: 8.39  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene