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MICAL2
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. Belongs to the Mical family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; EC 1.14.13.- |
| Chromosomal Location of human Ortholog: 11p15.3 |
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Cellular Component:
actin filament; cytoplasm; nucleus
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Molecular Function:
actin binding; FAD binding; metal ion binding; mitogen-activated protein kinase binding; monooxygenase activity; NAD(P)H oxidase H2O2-forming activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; protein binding
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Biological Process:
actin filament depolymerization; cytoskeleton organization; heart development; heart looping; positive regulation of transcription by RNA polymerase II; sulfur oxidation
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Reference #:
O94851
(UniProtKB)
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Alt. Names/Synonyms: [F-actin]-methionine sulfoxide oxidase MICAL2; [F-actin]-monooxygenase MICAL2; DKFZp686H03148; DKFZp686H2469; flavoprotein oxidoreductase MICAL2; KIAA0750; MICA2; MICAL-2; MICAL2; MICAL2PV1; MICAL2PV2; MICALCL; microtubule associated monooxygenase, calponin and LIM domain containing 2; microtubule associated monoxygenase, calponin and LIM domain containing 2; Molecule interacting with CasL protein 2; Protein MICAL-2; protein-methionine sulfoxide oxidase MICAL2
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Gene Symbols: MICAL2
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Molecular weight:
219,061 Da
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Basal Isoelectric point:
8.61
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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