MICAL2 Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. Belongs to the Mical family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; EC 1.14.13.-
Chromosomal Location of human Ortholog: 11p15.3
Cellular Component:  cytoplasm; nucleus
Molecular Function:  actin binding; FAD binding; metal ion binding; mitogen-activated protein kinase binding; NAD(P)H oxidase H2O2-forming activity; NADPH:sulfur oxidoreductase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; protein binding
Biological Process:  actin filament depolymerization; cytoskeleton organization; heart development; heart looping; positive regulation of transcription by RNA polymerase II; sulfur oxidation
Reference #:  O94851 (UniProtKB)
Alt. Names/Synonyms: [F-actin]-methionine sulfoxide oxidase MICAL2; [F-actin]-monooxygenase MICAL2; DKFZp686H03148; DKFZp686H2469; flavoprotein oxidoreductase MICAL2; KIAA0750; MICA2; MICAL-2; MICAL2; MICAL2PV1; MICAL2PV2; microtubule associated monooxygenase, calponin and LIM domain containing 2; microtubule associated monoxygenase, calponin and LIM domain containing 2; Molecule interacting with CasL protein 2; Protein MICAL-2; protein-methionine sulfoxide oxidase MICAL2
Gene Symbols: MICAL2
Molecular weight: 219,061 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below


Protein Structure Not Found.

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