PLRG1 Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Belongs to the WD repeat PRL1/PRL2 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; Spliceosome; Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 3|3 E3
Cellular Component:  catalytic step 2 spliceosome; Cul4-RING E3 ubiquitin ligase complex; fibrillar center; nuclear membrane; nuclear speck; nucleus; Prp19 complex; spliceosomal complex; U2-type catalytic step 2 spliceosome
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; positive regulation of G1/S transition of mitotic cell cycle; protein localization to nucleus; RNA splicing
Reference #:  Q922V4 (UniProtKB)
Alt. Names/Synonyms: AA958940; C80566; Pleiotropic regulator 1; pleiotropic regulator 1, PRL1 homolog; pleiotropic regulator 1, PRL1 homolog (Arabidopsis); Plrg1; Tan; Tango4
Gene Symbols: Plrg1
Molecular weight: 56,938 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene