DDX39 Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. Belongs to the DEAD box helicase family. DECD subfamily. Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary gland. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; RNA splicing; RNA-binding
Chromosomal Location of mouse Ortholog: 8|8 C2
Cellular Component:  cytoplasm; nuclear speck; nucleus
Molecular Function:  ATP binding; ATP hydrolysis activity; helicase activity; hydrolase activity; identical protein binding; nucleic acid binding; nucleotide binding; RNA binding; RNA helicase activity
Biological Process:  mRNA export from nucleus; mRNA processing; mRNA splicing, via spliceosome; RNA splicing
Reference #:  Q8VDW0 (UniProtKB)
Alt. Names/Synonyms: 2610307C23Rik; ATP-dependent RNA helicase DDX39; ATP-dependent RNA helicase DDX39A; BAT; BAT1; Ddx39; Ddx39a; DDXL; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39; DEAD box helicase 39a; DEAD box protein 39; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 39; DX39A; OTTMUSP00000031868; OTTMUSP00000031869; UAP56-related helicase, 49 kDa; URH49
Gene Symbols: Ddx39a
Molecular weight: 49,067 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DDX39

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene