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DDX39
Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. Belongs to the DEAD box helicase family. DECD subfamily. Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary gland. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.13; Helicase; RNA splicing; RNA-binding |
| Chromosomal Location of human Ortholog: 19p13.12 |
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Cellular Component:
cytoplasm; nuclear speck; nucleoplasm; nucleus
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Molecular Function:
ATP binding; ATP hydrolysis activity; identical protein binding; protein binding; RNA binding; RNA helicase activity
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Biological Process:
mRNA export from nucleus; mRNA splicing, via spliceosome; RNA export from nucleus
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Reference #:
O00148
(UniProtKB)
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Alt. Names/Synonyms: ATP-dependent RNA helicase DDX39; ATP-dependent RNA helicase DDX39A; BAT1; BAT1L; DDX39; DDX39A; DDXL; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 transcript; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A; DEAD box protein 39; DEAD-box helicase 39A; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 39; DExD-box helicase 39A; DX39A; MGC18203; MGC8417; Nuclear RNA helicase URH49; nuclear RNA helicase, DECD variant of DEAD box family; UAP56-related helicase, 49 kDa; URH49
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Gene Symbols: DDX39A
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Molecular weight:
49,130 Da
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Basal Isoelectric point:
5.46
Predict pI for various phosphorylation states
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