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MPRIP
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Rac/Rho |
| Chromosomal Location of human Ortholog: 17p11.2 |
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Cellular Component:
actin cytoskeleton; cytosol
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Molecular Function:
actin filament binding; protein binding
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Reference #:
Q6WCQ1
(UniProtKB)
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Alt. Names/Synonyms: KIAA0864; M-RIP; MPRIP; MRIP; myosin phosphatase Rho interacting protein; Myosin phosphatase Rho-interacting protein; myosin phosphatase-Rho interacting protein; p116Rip; Rho interacting protein 3; Rho-interacting protein 3; RHOIP3; RIP3
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Gene Symbols: MPRIP
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Molecular weight:
116,533 Da
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Basal Isoelectric point:
5.89
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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