MEF2C Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1. Belongs to the MEF2 family. Expressed in brain and skeletal muscle. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1q22
Cellular Component:  cytosol; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  activating transcription factor binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; histone acetyltransferase binding; histone deacetylase binding; protein dimerization activity; protein heterodimerization activity; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; SMAD binding; transcription coactivator activity
Biological Process:  apoptotic process; cardiac conduction; cellular response to calcium ion; cellular response to glucose stimulus; dendrite morphogenesis; ERK5 cascade; heart development; MAPK cascade; mitochondrial genome maintenance; mitochondrion distribution; negative regulation of transcription by RNA polymerase II; positive regulation of cardiac muscle hypertrophy; positive regulation of glucose import; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; ventricular cardiac myofibril assembly
Reference #:  Q2MJT0 (UniProtKB)
Alt. Names/Synonyms: Mef2a; MEF2C; myocyte enhancer factor 2a; Myocyte-specific enhancer factor 2A
Gene Symbols: Mef2a
Molecular weight: 53,254 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Regulation of P38 MAPKs
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene