hnRNP M Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA splicing; RNA-binding; Receptor, misc.; Spliceosome
Chromosomal Location of human Ortholog: 19p13.2
Cellular Component:  catalytic step 2 spliceosome; nuclear matrix; nucleolus; nucleoplasm; paraspeckles; spliceosomal complex
Molecular Function:  protein binding; protein domain specific binding; RNA binding
Biological Process:  alternative mRNA splicing, via spliceosome; fibroblast growth factor receptor signaling pathway; mRNA splicing, via spliceosome; RNA metabolic process
Reference #:  P52272 (UniProtKB)
Alt. Names/Synonyms: CEA receptor; CEAR; DKFZp547H118; Heterogeneous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4; hnRNP M; HNRNPM; HNRNPM4; HNRPM; HNRPM4; HTGR1; M4 protein; N-acetylglucosamine receptor 1; NAGR1
Gene Symbols: HNRNPM
Molecular weight: 77,516 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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hnRNP M

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein