CPSF6 Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export. Belongs to the RRM CPSF6/7 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA-binding; Spliceosome
Chromosomal Location of human Ortholog: 12q15
Cellular Component:  cytoplasm; interchromatin granule; mRNA cleavage and polyadenylation specificity factor complex; mRNA cleavage factor complex; nuclear speck; nucleoplasm; nucleus; paraspeckles; perichromatin fibrils; ribonucleoprotein complex
Molecular Function:  exon-exon junction complex binding; mRNA binding; protein binding; ribosomal large subunit binding; RNA binding
Biological Process:  localization; messenger ribonucleoprotein complex assembly; mRNA 3'-end processing; mRNA alternative polyadenylation; mRNA processing; positive regulation of RNA export from nucleus; protein heterotetramerization; protein tetramerization
Reference #:  Q16630 (UniProtKB)
Alt. Names/Synonyms: CFIM; CFIM68; CFIM72; cleavage and polyadenylation specific factor 6; cleavage and polyadenylation specific factor 6, 68kDa; Cleavage and polyadenylation specificity factor 68 kDa subunit; Cleavage and polyadenylation specificity factor subunit 6; Cleavage factor Im complex 68 kDa subunit; CPSF 68 kDa subunit; CPSF6; HPBRII-4; HPBRII-7; pre-mRNA cleavage factor I, 68kD subunit; pre-mRNA cleavage factor Im (68kD); Pre-mRNA cleavage factor Im 68 kDa subunit; Protein HPBRII-4/7
Gene Symbols: CPSF6
Molecular weight: 59,210 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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