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GPSM1
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family. Expressed in intestinal cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, misc. |
| Chromosomal Location of human Ortholog: 9q34.3 |
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Cellular Component:
cell cortex; cytosol; endoplasmic reticulum membrane; Golgi membrane; plasma membrane; protein-containing complex
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Molecular Function:
G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; protein binding
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Biological Process:
cell differentiation; establishment of mitotic spindle orientation; negative regulation of GTPase activity; negative regulation of guanyl-nucleotide exchange factor activity; nervous system development; positive regulation of macroautophagy
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Reference #:
Q86YR5
(UniProtKB)
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Alt. Names/Synonyms: 1810037C22Rik; Activator of G-protein signaling 3; AGS3; DKFZp727I051; G protein signaling modulator 1; G-protein signaling modulator 1 (AGS3-like, C. elegans); G-protein signalling modulator 1 (AGS3-like, C. elegans); G-protein-signaling modulator 1; GPSM1
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Gene Symbols: GPSM1
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Molecular weight:
74,510 Da
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Basal Isoelectric point:
6.1
Predict pI for various phosphorylation states
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