PAR-4 a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 7q21
Cellular Component:  actin filament; axon; cytoplasm; neuron projection; neuronal cell body; nuclear chromatin; nucleus
Molecular Function:  actin binding; enzyme binding; leucine zipper domain binding; protein binding; protein kinase C binding; protein phosphatase 1 binding
Biological Process:  actin filament bundle assembly; activation of cysteine-type endopeptidase activity; apoptotic process; apoptotic signaling pathway; calcium ion import across plasma membrane; cellular response to estradiol stimulus; cellular response to follicle-stimulating hormone stimulus; cellular response to interleukin-1; cellular response to vitamin E; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; interleukin-2 biosynthetic process; negative regulation of B cell proliferation; negative regulation of calcium ion import; negative regulation of fibroblast proliferation; negative regulation of gene expression; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of action potential; positive regulation of amyloid precursor protein biosynthetic process; positive regulation of apoptotic process; positive regulation of cellular senescence; positive regulation of gene expression; positive regulation of hindgut contraction; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of leukocyte tethering or rolling; positive regulation of neuron apoptotic process; positive regulation of neuronal action potential; positive regulation of neutrophil extravasation; positive regulation of phosphoprotein phosphatase activity; positive regulation of relaxation of smooth muscle; response to estradiol; response to iron(II) ion; response to lipopolysaccharide; response to wounding
Reference #:  Q62627 (UniProtKB)
Alt. Names/Synonyms: Par-4; par-4 induced by effectors of apoptosis; Par4; Pawr; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; Prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; Transcriptional repressor Par-4-like protein PAWR
Gene Symbols: Pawr
Molecular weight: 35,866 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PAR-4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene