Gelsolin Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Belongs to the villin/gelsolin family. Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component:  actin cap; actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytosol; extracellular region; extracellular space; ficolin-1-rich granule lumen; lamellipodium; myelin sheath; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; podosome; ruffle; sarcoplasm; secretory granule lumen
Molecular Function:  actin binding; actin filament binding; calcium ion binding; myosin II binding; protein binding
Biological Process:  actin filament capping; actin filament polymerization; actin filament reorganization; actin filament severing; actin nucleation; aging; amyloid fibril formation; barbed-end actin filament capping; cellular protein metabolic process; cellular response to cadmium ion; cellular response to interferon-gamma; cilium assembly; hepatocyte apoptotic process; negative regulation of viral entry into host cell; neutrophil degranulation; oligodendrocyte development; phagocytosis, engulfment; phosphatidylinositol-mediated signaling; positive regulation of actin nucleation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of gene expression; positive regulation of keratinocyte apoptotic process; positive regulation of protein processing in phagocytic vesicle; protein destabilization; regulation of cell adhesion; regulation of establishment of T cell polarity; regulation of plasma membrane raft polarization; regulation of podosome assembly; regulation of receptor clustering; renal protein absorption; response to ethanol; response to folic acid; sequestering of actin monomers; striated muscle atrophy; tissue regeneration
Disease: Amyloidosis, Finnish Type
Reference #:  P06396 (UniProtKB)
Alt. Names/Synonyms: Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; epididymis secretory sperm binding protein; GELS; Gelsolin; gelsolin (amyloidosis, Finnish type); GSN
Gene Symbols: GSN
Molecular weight: 85,698 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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