Gelsolin a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component:  actin cap; actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytosol; extracellular region; extracellular space; ficolin-1-rich granule lumen; lamellipodium; myelin sheath; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; podosome; ruffle; sarcoplasm; secretory granule lumen
Molecular Function:  actin binding; actin filament binding; calcium ion binding; myosin II binding; protein binding
Biological Process:  actin filament capping; actin filament polymerization; actin filament reorganization; actin filament severing; actin nucleation; aging; amyloid fibril formation; barbed-end actin filament capping; cellular protein metabolic process; cellular response to cadmium ion; cellular response to interferon-gamma; cilium assembly; hepatocyte apoptotic process; negative regulation of viral entry into host cell; neutrophil degranulation; oligodendrocyte development; phagocytosis, engulfment; phosphatidylinositol-mediated signaling; positive regulation of actin nucleation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of gene expression; positive regulation of keratinocyte apoptotic process; positive regulation of protein processing in phagocytic vesicle; protein destabilization; regulation of cell adhesion; regulation of establishment of T cell polarity; regulation of plasma membrane raft polarization; regulation of podosome assembly; regulation of receptor clustering; renal protein absorption; response to ethanol; response to folic acid; sequestering of actin monomers; striated muscle atrophy; tissue regeneration
Disease: Amyloidosis, Finnish Type
Reference #:  P06396 (UniProtKB)
Alt. Names/Synonyms: Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; GELS; Gelsolin; gelsolin (amyloidosis, Finnish type); GSN
Gene Symbols: GSN
Molecular weight: 85,698 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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