Gelsolin
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Belongs to the villin/gelsolin family. Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide |
Chromosomal Location of Human Ortholog: 9q33.2 |
Cellular Component:
actin cap; actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytosol; extracellular region; extracellular space; ficolin-1-rich granule lumen; lamellipodium; myelin sheath; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; podosome; ruffle; sarcoplasm; secretory granule lumen
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Molecular Function:
actin binding; actin filament binding; calcium ion binding; myosin II binding; protein binding
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Biological Process:
actin filament capping; actin filament polymerization; actin filament reorganization; actin filament severing; actin nucleation; aging; amyloid fibril formation; barbed-end actin filament capping; cellular protein metabolic process; cellular response to cadmium ion; cellular response to interferon-gamma; cilium assembly; hepatocyte apoptotic process; negative regulation of viral entry into host cell; neutrophil degranulation; oligodendrocyte development; phagocytosis, engulfment; phosphatidylinositol-mediated signaling; positive regulation of actin nucleation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of gene expression; positive regulation of keratinocyte apoptotic process; positive regulation of protein processing in phagocytic vesicle; protein destabilization; regulation of cell adhesion; regulation of establishment of T cell polarity; regulation of plasma membrane raft polarization; regulation of podosome assembly; regulation of receptor clustering; renal protein absorption; response to ethanol; response to folic acid; sequestering of actin monomers; striated muscle atrophy; tissue regeneration
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Disease: Amyloidosis, Finnish Type
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Reference #:
P06396
(UniProtKB)
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Alt. Names/Synonyms: Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; epididymis secretory sperm binding protein; GELS; Gelsolin; gelsolin (amyloidosis, Finnish type); GSN
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Gene Symbols: GSN
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Molecular weight:
85,698 Da
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Basal Isoelectric point:
5.9
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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