BID The major proteolytic product p15 BID allows the release of cytochrome c. Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Mitochondrial
Chromosomal Location of rat Ortholog: 4q42
Cellular Component:  cytoplasm; cytosol; integral component of mitochondrial membrane; membrane; mitochondrial outer membrane; mitochondrion
Molecular Function:  protein binding; protein heterodimerization activity; ubiquitin protein ligase binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic mitochondrial changes; brain development; establishment of protein localization to membrane; extrinsic apoptotic signaling pathway; glial cell apoptotic process; hepatocyte apoptotic process; mitochondrial ATP synthesis coupled electron transport; mitochondrial outer membrane permeabilization; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of autophagy in response to ER overload; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of fibroblast apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial membrane potential; positive regulation of protein homooligomerization; positive regulation of protein oligomerization; positive regulation of release of cytochrome c from mitochondria; protein homooligomerization; protein targeting to mitochondrion; regulation of apoptotic process; regulation of cell proliferation; regulation of G1/S transition of mitotic cell cycle; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of protein oligomerization; release of cytochrome c from mitochondria; response to estradiol; response to ischemia
Reference #:  Q9JLT6 (UniProtKB)
Alt. Names/Synonyms: apoptotic death agonist BID; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; BID; desmocollin type 4; p11 BID; p13 BID; p15 BID; p22 BID
Gene Symbols: Bid
Molecular weight: 22,249 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene